Chemistry of Biomacromolecules

Researcher
Address: Circuito Exterior s/n, Ciudad Universitaria. District Coyoacán. ZIP Code 04510 Mexico City. Mexico

Telephone: +52 (55) 56-22-45-48

ACADEMIC SUMMARY

The Prof. Armando Hernandez-Garcia was born in Mexico City on 1981. In 2007 he got a BSc. degree with major in Food Chemistry in the Chemistry School of the National Autonomous University of Mexico (UNAM). Later he carried a MSc. degree in Lund University, Sweden between graduating in 2009 with a thesis under supervision of Prof. Sara Linse in the department of Biophysical Chemistry (now in Biochemistry). His doctoral studies were done in the Laboratory of Physical chemistry and soft matter of Wageningen University in the Netherlands under the supervision of Prof. Martien Cohen Stuart and Dr. Renko de Vries, graduating in 2014 with a “very exceptional almost excellent thesis dissertation”. In 2014 he received the prestigious award PEW biomedical Fellowship for Latin Americans to carry his postdoctoral research in the lab of Prof. Samuel Stupp in Northwestern University in Chicago, USA. In 2016 he entered to the Chemistry Institute of the UNAM to start his career as independent researcher and Professor in the lab of Biomolecular Engineering and Bionanotechnology.

BSc (Food Chemistry), UNAM, 2007.

MSc (Biotechnology), Lund University, Sweden, 2009.

PhD (Protein Engineering, Physical chemistry and soft matter), Wageningen University, the Netherlands, 2014.

Postdoctorate. Simpson Querrey Institute, Universidad de Northwestern, Chicago, EEUU, 2016.

RESARCH TOPICS

The laboratory of Biomolecular Engineering and Bionanotechnology (BioNano) develops improved, optimized, programmable, standardized and simplified versions of proteins for building, together with DNA, supramolecular nanomaterials with augmented capabilities and controlled physical and chemical properties and applied them in innovative ways for healthcare, food security and sustainable energy.

We look to connect basic research about Biomolecular Engineering and Bionanotechnology with technological development and innovation. We carried out multi and interdisciplinary projects combining experimental methodologies coming from molecular and structural biology, biophysics, biochemistry, physical chemistry, organic synthesis, material and polymer science and biomedical sciences. As consequence, chemists, biologist, physicist, engineers and health specialist, have a place to work together.

Our research has three main goals:

1) Through the design of novel and artificial proteins and peptides and their assemblies we look to understand the forces that dictate function, structure and self-assembly properties. We apply the principle “If I can design it, then I can understand it”.

2) To establish guidelines that help to design novel and synthetic proteins and peptides in order to self-assemble in supramolecular nanostructures with defined and controlled shape, architecture, size and properties.

3) To study the interaction between synthetic proteins and peptides with cells and organisms.

TEACHING ACTIVITIES

BIONANOTECHNOLOGY for BSc. School of Chemistry, UNAM

ADVANCED BIONANOTECHNOLOGY for MSc and PhD in Chemistry, Biochemistry and Biomedical sciences, UNAM.

 We are looking for enthusiastic people interested to carry out projects in the interface of Biochemistry, nanotechnology and synthetic biology. There is possibility to fund thesis and internships for BSc, MSc and PhD, and also for postdoctorate research.

AWARDS AND HONORS

• 2016 National Researcher Mexico – CONACyT (level 1).
• 2014 PEW Latin American Fellow, USA.
• 2009 Dutch Polymer Institute Fellowship, the Netherlands.
• 2009 Abroad PhD studies grant CONACyT, Mexico.
• 2007 Abroad MSc studies grant FUNED, Mexico.

SCIENCE POPULARIZATION

Blog about bionanotechnology

(http://bionanotecnologias.blogspot.mx)

RECENT PUBLICATIONS

• N. A. Estrich, A. Hernandez-Garcia, R. de Vries, T. H. LaBean. Engineered Diblock Polypeptides Improve DNA and Gold Solubility during Molecular Assembly. ACS Nano. DOI: 10.1021/acsnano.6b07291 (2017).

  • A. Hernandez-Garcia, N. A. Estrich, M. T. W. Werten, J. Van der Maarel, T. H. LaBean, F. A. de Wolf, M.A.C. Stuart, R. de Vries. Precise Coating of a Wide Range of DNA Templates by a Protein Polymer with a DNA Binding Domain. ACS Nano. DOI: 10.1021/acsnano.6b05938 (2016).

  • A. Hernandez-Garcia, A.H. Velders, M.A.C. Stuart, R. de Vries, J.W.M. van Lent, J. Wang. Hybrid nanomaterials: Self-Assembly of Metal Ions into Nanorods Using an Artificial Viral Coat Protein. Chemistry – A European Journal. Aceptado (2016).

  • M. Punter, A. Hernandez-Garcia, D.J. Kraft, P. van der Schoot, R. de Vries. Self-Assembly Dynamics of Linear Virus-Like Particles: Theory and Experiment. Journal of Physical Chemistry B, 120 (26), 6286–6297 (2016).

  • I.M. Storm, M. Kornreich, A. Hernandez-Garcia, I.K Voets, R. Beck, M.A.C. Stuart, F.A.M. Leermakers, R. de Vries. Liquid Crystals of Self-Assembled DNA Bottlebrushes. Journal of Physical Chemistry B, 119 (10), 4084-4092 (2015).

  • A. Hernandez-Garcia, D.J. Kraft, A.F.J. Janssen, P.H.H. Bomans, N.A.J.M. Sommerdijk, D.M.E. Thies-Weesie, M.E. Favretto, R. Brock, F.A. de Wolf, M.W.T. Werten, P. van der Schoot, M.C. Stuart, R. de Vries. Supramolecular Design of a Minimal Coat-Protein for an Artificial Virus. Nature Nanotechnology, 9, 698–702 (2014).

  • Zhang, A. Hernandez-Garcia, K. Jiang, Z. Gong, D. Guttula, S.Y. Ng, P.P. Malar, J.A. van Kan, L. Dai, P.S. Doyle, R. de Vries, J.R.C. van der Maarel. Amplified Stretch of Bottlebrush-Coated DNA in Nanofluidic Channels. Nucleic Acids Research, 41 (20), e189 (2013).

  •M.D. Golinska, F.A. de Wolf, M.C. Stuart, A. Hernandez-Garcia, R. de Vries. Pearl-Necklace Complexes of Flexible Polyanions with Neutral-Cationic Diblock Copolymers. Soft Matter, 9 (28), 3491-3501 (2013).

  •A. Hernandez‐Garcia, M.W.T. Werten, M.C. Stuart, F.A. de Wolf, R. de Vries. Coating of Single DNA Molecules by Genetically Engineered Protein Diblock Copolymers. Small, 8 (22), 3491-3501 (2012).

  •S. Lindman, A. Hernandez-Garcia, O. Szczepankiewicz, B. Frohm, S. Linse. In Vivo Protein Stabilization Based on Fragment Complementation and a Split GFP System. Proc. Natl. Acad. Sci. USA. 107, 19826-31 (2010).

  
  

Dr. Annia Rodríguez Hernández

Academic Technician, National Laboratory of Molecular Structure (LANEM)

Address:Circuito Exterior s/n, Ciudad Universitaria. Delegación Coyoacán, C.P.04360
Cd. Mx

Phone: +52 (55) 5622 4615

             +52  56 22 47 70 ext.: 24615

Laboratory 1 and 2 RMN
Building A, first floor

ACADEMIC BACKGROUND 

Academic Technician at the National Laboratory of Molecular Structure (LANEM), Institute of Chemistry, UNAM, June 1, 2016; B. Sc. in Biochemical Engineering, Zacatepec Institute of Technology, (June 2006); Ph. D. in Chemistry (Area: Biochemistry), University of California-Santa Barbara, USA (September 2011); Research Assistant, Portland State University (PSU), Portland Oregon, USA (September 2011-August 2012); Postdoctoral Researcher, Institute of Cellular Physiology, UNAM (September 2012-April 2015); Postdoctoral Researcher LANGEBIO-CINVESTAV, IPN (May 2015-April 2016). 

Research Stays abroad: National Synchrotron Radiation Research Center, Hsinchu, Taiwan (March-April 2015), California NanoSystems Institute, and Mechanical Engineer Department, University of California-Santa Barbara, USA (July-August 2014 and January-February 2015).

Department of Physical Chemistry

Researcher
Address:Circuito Exterior s/n, Ciudad Universitaria. District Coyoacán. ZIP Code 04510 Mexico City. Mexico

Telephone: +52 (55) 56 22 47 70 ext. 46616

Fax: +52 (55) 56-16-22-17

ACADEMIC SUMMARY

Dr. Anna Kozina graduated from the Mendeleev University of Chemical Technology of Russia in Moscow in 2005 with the title of chemical engineer and the Diploma with honours in specialty ‘Technology of pharmaceutical and cosmetic products’. For her PhD she was invited by the group of Prof. Eckhard Bartsch at the University of Freiburg, Germany, where she studied the structure, dynamics and rheological properties of highly concentrated colloidal dispersions. After receiving her PhD in 2009 she joined the group of Dr. Tessy Lopez at the National Institute of Neurology and Neurosurgery in Mexico as a postdoctoral fellow.

Also, she worked as a postdoc with Prof. Ignacio Rivero at the Nacional Institute of Nuclear Research in Mexico and with Dr. Rolando Castillo at the Institute of Physics at the National University of Mexico.

RESEARCH  

• Phase behaviour, structure and dynamics of highly concentrated colloidal dispersions.

• Rheology of complex fluids.

• Synthsis and characterization of model colloidal particles.

• Development, synthesis, characterization of nanostructured materials for different applications. 

TEACHING ACTIVITIES

Scholarships are available for the students of different levels interested in working in the group.

Chemical Kinetics and Catalysis, Faculty of Chemistry, UNAM

AWARDS AND HONORS

Mexican National Research System, Level I.

Member of the Mexican Soft Condensed Matter Network

RECENT PUBLICATIONS

A. Kozina, P. Díaz-Leyva, T. Palberg and E. Bartsch. ‘Crystallization kinetics of colloidal binary mixtures with depletion attraction’, Soft Matter, 10, 9523-9533, 2014. 

A. Kozina, J. L. Iturbe and I. A. Rivero. ‘Selective Reduction of Phenyacetylene with AlMgO Particles used as an Alternative Water-Reactive Generator of Hydrogen’, Catt. Lett., 143, 739-747, 2013. 

A. Kozina, P. Díaz-Leyva, Chr. Friedrich, and E. Bartsch. ‘Structural and Dynamical Evolution of Colloid-Polymer Mixtures on crossing Glass and Gel Transition as seen by Optical Microrheology and Mechanical Bulk Rheology’, Soft Matter, 8, 1033-1046, 2012.

A. Kozina, D. Sagawe, P. Díaz-Leyva, E. Bartsch, and T. Palberg. ‘Polymer-Enforced Crystallization of a Eutectic Binary Hard Sphere Mixture’, Soft Matter, 8, 627-630, 2012.

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Chemistry of Biomacromolecules

Researcher
Address:Circuito Exterior s/n, Ciudad Universitaria.District Coyoacán. ZIP Code 04510

 Mexico City. Mexico

Telephone: +52 (55) 56-22-47-70 ext. 46612
Fax: +52 (55) 56-16-22-17

ACADEMIC SUMMARY

Hector Viadiu studied Biology at the Faculty of Sciences in the National Autonomous University of Mexico (UNAM). He later studied a Master in Biotechnology from the Institute of Biotechnology also at UNAM studying in-vitro evolution and enzyme kinetics of beta-lactamases. He carried out his doctoral studies at Columbia University studying the specificity of restriction endonucleases by X-ray crystallography. He realized his postdoctoral studies at Harvard Medical School in several projects learning cryo-electron microscopy. Later on, he started his career as independent investigator at the University of California. He recently rejoined his alma mater UNAM as a Faculty in the Chemistry Institute.

RESEARCH TOPICS

Dr. Viadiu is an expert in protein structure determination by electron microscopy single particle analysis, electron crystallography, and X-ray crystallography. His work has focused mainly on proteins that bind DNA and, in a lesser degree, on membrane proteins.

In particular, he has focused on understanding the structure of proteins involved in cancerous processes. Dr. Viadiu is a leader in the study of the transcription factors of the p53 protein family. His research group has solved the structure of the protein most frequently mutated in cancerous cells, p53, at an unprecedented resolution to explain differences in its ability to trigger differential gene expression. His research group also solved for first time the DNA-binding domain of p73, a p53-related protein. In order to suggest new cancer treatments, his work aims to understand how the p73 protein can replace the function of the mutated p53 protein in cancerous cells. He has defined the differences in the specificity profiles of these two important proteins.

TEACHING ACTIVITIES

Dr. Viadiu has overseen the work of 4 postdoctoral fellows, 1 Ph.D. Student and 11 M.Sc. Students.

Dr. Viadiu has taught the following graduate and undergraduate courses at the University of California.

01/2014 -­ 04/2014 Electron Microscopy of Macromolecules - GRADUATE COURSE

01/2013 -­ 04/2013 Electron Microscopy of Macromolecules - GRADUATE COURSE

09/2012 -­ 12/2012 Electron Microscopy of Macromolecules - GRADUATE COURSE

09/2012 -­ 12/2012 Structural Biochemistry - UNDERGRADUATE COURSE

09/2011 -­ 12/2011 Structural Biochemistry - UNDERGRADUATE COURSE

01/2011 -­ 04/2011 Introduction to Protein Crystallography - GRADUATE COURSE

09/2010 -­ 12/2010 Structural Biochemistry - UNDERGRADUATE COURSE

09/2009 -­ 12/2009 Structural Biochemistry - UNDERGRADUATE COURSE

09/2009 -­ 12/2009 Macromolecular Recognition - GRADUATE COURSE

09/2008 -­ 12/2008 Structural Biochemistry - UNDERGRADUATE COURSE

01/2008 -­ 04/2008 Structural Biochemistry - UNDERGRADUATE COURSE

01/2008 -­ 04/2008 Introduction to Protein Crystallography - GRADUATE COURSE

Please, contact him by email, regarding the possibility to carry out research work at the postdoctoral, Ph.D., M.Sc., and B.Sc. levels in his laboratory.

RECENT PUBLICATIONS

1. Structural studies on mechanisms to activate mutant p53.Viadiu H, Fronza G, Inga A. Subcell Biochem. 2014;85: 119-32. doi: 10.1007/978-94-017-9211-0_7. Review. PMID: 25201192.

2. Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code. Ciribilli Y, Monti P, Bisio A, Nguyen HT, Ethayathulla AS, Ramos A, Foggetti G, Menichini P, Menendez D, Resnick MA, Viadiu H, Fronza G, Inga A. Nucleic Acids Res. 2013 Oct;41(18):8637-53. doi: 10.1093/nar/gkt657. Epub 2013 Jul 26. PMID: 23892287.

3. Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements. Ethayathulla AS, Nguyen HT, Viadiu H. J Biol Chem. 2013 Feb 15; 288(7):4744-54. doi: 10.1074/jbc.M112.408039. Epub 2012 Dec 14. PMID: 23243311.

4. The tetramer of p53 in the absence of DNA forms a relaxed quaternary state. Pham N, Lucumi A, Cheung N, Viadiu H. Biochemistry. 2012 Oct 16;51(41):8053-5. doi: 10.1021/bi301193k. Epub 2012 Oct 2. PMID: 23025236.

5. Structure of p73 DNA-binding domain tetramer modulates p73 transactivation. Ethayathulla AS, Tse PW, Monti P, Nguyen S, Inga A, Fronza G, Viadiu H. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6066-71. doi: 10.1073/pnas.1115463109. Epub 2012 Apr 2.PMID: 22474346.

6. Projection map of aquaporin-9 at 7 A resolution. Viadiu H, Gonen T, Walz T. J Mol Biol. 2007 Mar 16;367(1):80-8. Epub 2006 Dec 20. PMID: 17239399.

7. Domain structure of separase and its binding to securin as determined by EM. Viadiu H, Stemmann O, Kirschner MW, Walz T. Nat Struct Mol Biol. 2005 Jun;12(6):552-3. Epub 2005 May 8. PMID: 15880121.

8. Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. Scully KM, Jacobson EM, Jepsen K, Lunyak V, Viadiu H, Carrière C, Rose DW, Hooshmand F, Aggarwal AK, Rosenfeld MG. Science. 2000 Nov 10; 290 (5494):1127-31. PMID: 11073444.

9. Structure of BamHI bound to nonspecific DNA: a model for DNA sliding. Viadiu H, Aggarwal AK. Mol Cell. 2000 May; 5 (5):889-95. PMID: 10882125.

10. The role of metals in catalysis by the restriction endonuclease BamHI. Viadiu H, Aggarwal AK. Nat Struct Biol. 1998 Oct; 5(10):910-6. PMID: 9783752.

Department of Physical Chemistry

Researcher
Address:Circuito Exterior s/n, Ciudad Universitaria. District Coyoacán. ZIP Code 04510 Mexico City. Mexico

Telephone: +52 (55) 56 22 47 70 . Ext: 46614
Fax: +52 (55) 56-16-22-17

ACADEMIC SUMMARY

Karina Martinez-Mayorga earned her Bachelor of Science in Chemistry in 1998 and her Ph.D. in 2005 with Professor Gabriel Cuevas, both from the National Autonomous University of Mexico (Universidad Nacional Autonoma de Mexico-UNAM) in Mexico City. During her doctoral studies, she participated in research visits with Professor Jesus Jimenez-Barbero in Madrid, Spain, and instructed in the School of Chemistry at UNAM and La Salle University. In February 2005, Dr. Martinez-Mayorga joined the group of Professor Michael F. Brown at the University of Arizona as a postdoctoral fellow, conducting experimental and computational research on membrane proteins and membrane lipids.  In August 2007, she joined the Torrey Pines Institute for Molecular Studies in Florida as Assistant Member.

RESEARCH TOPICS

Dr. Martínez-Mayorga´s research focuses on the development of structural models to understand molecular recognition processes employing computational and spectroscopic techniques. Current areas of interest include the development of antiparasitic and analgesic agents. In addition, Dr. Martínez-Mayorga´s lab is employing computational methods to investigate the potential role of flavor chemicals as bioactive molecules.

TEACHING AND OUTREACH ACTIVITIES

Teaching

• General chemistry lab, School of Chemistry, National Autonomous University of Mexico, Mexico City

• General chemistry, analytical chemistry lab, kinetics lab, La Salle University, Mexico City

Posdoctoral fellows

          Austin B. Yongye, Kendall Byler, Thomas Caulfield

Undergrad student

• Veronica Leiva Novoa: graduated in 2004

Thesis reviewer

• Ph. D. thesis evaluator. Title: “MOLSDOCK: Applications of the molecular docking algorithm using mutually orthogonal Latin squares” by S. Nehru Viji. University of Madras, Tamil Nadu, India

Outreach activities

 Reviewer for grant proposal applications: National Council of Science and Technology (CONACyT), Austrian Science Fund (FWF), and Czech Science Foundation.

Reviewer for Scientific Journals.

“Taller de Modelado Molecular”, Universidad Autónoma Metropolitana, Unidad Xochimilco, Mexico City. Mexico, September 29^th, 2011.

Indian River State College, Port St. Lucie, FL, 9^th annual Youth Summit, March 13^th, 2010.

St. Lucie County Regional Science and Engineering Fair, Harvent L. Fenn Center, Fort Pierce, FL, February 1, 2011. 

AWARDS AND HONORS

• Member of the National System of Research, Mexico (SNI-CONACyT), level II.

• Presentation of the press conference “Good mood foods: Some flavors in some foods resemble a prescription mood stabilizer” at the 244^th American Chemical Society National Meeting & Exposition in Philadelphia PA, with approximately 14,700 commentaries and news online.

• Travel award granted by the Agricultural and Food Chemistry Division of the American Chemical Society to participate in the “Young Scientist Award Symposium” August 21, 2012.

• Award granted by Robertet Flavors, Inc. 2011, 2012.

• Antonio Caso Medal postulate for PhD, studies. National Autonomous University of Mexico, 2005.

• Outstanding Teacher, La Salle University, 2004.

• Science and Technology National Council Fellowship at the National Autonomous University of Mexico, PhD studies, January 01, 2001- Dec 31, 2003.

RECENT/RELEVANT PUBLICATIONS

Chaker, L.; Yongye, A. B.; Nefzi, A.; Martinez-Mayorga, K. “Prediction of the experimental regioselectivity of C60 fullerene bis-adducts” J. Phys. Org. Chem. 2012, 25, 94-901.

Yongye, A. B.; Calle, L.; Arda, A.; Jimenez-Barbero, J.; Andre, S.; Gabius, H.-J.; Martinez-Mayorga, K.; Cudic, M. “Binding recognition of Thomsen-Friedenrich antigen by chicken Galectin-3” Biochemistry 2012, 51, 7278-7289.

Lopez-Vallejo, F.; Martinez-Mayorga, K. “Furin inhibitors: Importance of the positive formal charge and beyond” Bioorg. Med. Chem 2012, 20, 4462-4471.

Byler, K.; Brito-Arias, M.; Marquez-Navarro, A.; Nogueda-Torres, B.; Torres, L. G.; Martinez-Mayorga,K. “Identification of benzoylisoquinolines as potential anti-Chgas agents” 2012, Bioor. Med. Chem. 2012, 20, 2587-2594.

Vivoli, M. Caulfield, T. R.; Martinez-Mayorga, K.; Johnson, A. T.; Jiao, G-S, Lindberg, I. “Inhibition of PC1/3 and PC2 by 2,5-dideoxystreptamine derivatives” Mol. Pharmacol. 2012, 81, 440-454.

Martinez-Mayorga, K.; Peppard, T.; Yongye, A. B.; Santos, R.; Giulianotti, M.; Medina-Franco, J. M. “Characterization of a comprehensive flavor database” J. Chemometrics 2011, 25, 550-560.

Lopez-Vallejo, F.’ Peppard T. L.; Medina-Franco. J. L.; Martinez-Mayorga, K. “Computational Methods for the discovery of Mood disorder therapy” Expert Opin. Drug Discovery 2011, 6, 1227-1245.

Struts, A.V.; Salgado, G. F.; Martinez-Mayorga, K.; Brown, M. F. “Retinal Dynamics Underlie Inverse-Agonist to Agonist Switch in Rhodopsin Activation” Nat. Struct. Mol. Biol. 2011, 18, 392-394.

Yongye, A. B.; Bender, A.; Martínez-Mayorga, K. “Dynamic clustering threshold reduces conformer ensemble size while maintaining a biologically relevant ensemble” J. Comput.-Aided Mol. Des. 2010, 24, 675-686.

Yongye, B. A.; Appel, J. R.; Giulianotti, M. A.; Colette, T. D.; Medina-Franco, J. L.; Nefzi, A.; Houghten, R. A.; Martínez-Mayorga, K. “Identification, Structure Activity Relationships and Molecular Modeling of Potent Triamine and Piperazine Opioid Ligands” Bioorg. Med. Chem, 2009, 17, 5583-5597.

Yongye, B. A.; Li, Y.; Giulianotti, M. A.; Yu. Y.; Houghten, R. A.; Martínez-Mayorga, K. “Modeling of Peptides Containing D-Amino Acids: Implications on Cyclization” J. Comput.-Aided Mol. Des. 2009, 23, 677-689.

Mahalingam, M.; Martínez-Mayorga, K.; Brown, M. F.; Vogel, R. “Two protonation switches control rhodopsin activation in membranes” Proc. Natl. Acad. Sci., 2008, 105, 17795-17800.

Martínez-Mayorga, K.; Medina-Franco, J. L.; Giulianotti, M. A.; Pinilla, C.; Dooley, C. T.; Appel, J. R.; Houghten, R. A. “Conformation-Opioid Activity Relationships of Bicylcic Guanidines from 3D Similarity Analysis” Bioorg. Med. Chem., 2008 16, 5932-5938.

Martínez-Mayorga, K.; Pitman, M. C.; Groessfield, A.; Feller, S. E.; Brown, M. F. “Retinal Counterion Switch Mechanism in Vision Evaluated by Molecular Simulations” J. Am. Chem. Soc. 2006, 128, 16502-16503.

Cuevas, G.; Martínez-Mayorga, K.; Fernandez-Alonso, M. del. C.; Jiménez-Barbero, J.; Perrin, C. L.; Juaristi, E.; López-Mora, N. “The Origin of One-Bond C-H Coupling Constants in OCH Fragments: Not Primarily n_O ® *_CH Delocalization” Angew. Chem. Int. Ed. Engl. 2005, 44, 2360-2364.

Martínez-Mayorga, K.; Juaristi, E.; Cuevas, G. “Manifestation of Steroelectronic Effects on the Calculated Carbon-Hydrogen Bond Lengths and One Bond ¹J_C-H NMR Coupling Constants. Relative Acceptor Ability of the Carbonyl Group (C=O), Thiocarbonil (C=S), and Methylidene (C=CH₂) Groups Towards C-H Donor Bonds” J. Org. Chem. 2004, 69, 7266-7276.

Martínez-Mayorga, K.; Medina-Franco, J. L.; Mari, S.; Cañada, F. J.; Rodríguez-García, E.; Vogel, P.; Li, H.; Bleriot, Y.; Sinaÿ, P.; and Jiménez-Barbero, J. “The conformational behavior of novel glycosidase inhibitors with substituted azepan structures. A NMR and modeling study” Euro. J. Org. Chem. 2004, 4119-4129.

Book chapters

Yongye, A. B.; Martinez-Mayorga, K. “Molecular Aspects of opioid receptors and opioid receptors painkillers” in “Pain Management” Gabor B. Racz and Carl E. Noe (Eds.) ISBN: 978-953-307-813-7, InTech Available from: http://www.intechopen.com/

Martinez-Mayorga Karina, Medina-Franco, Jose Luis “Chemoinformatics: Applications in Food Chemistry” in “Advances in Food and Nutrition Research” Steve Taylor (Ed.) Vol. 58 Burlington: Academic Press - Elsevier Inc. 2009, pp. 33-56.