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RESUME
Dr. Rodríguez-Romero
received her Ph.D. in Chemistry from the UAM-I in 1991, specializing in
Protein Crystallography. She spent one year (95-96) at the Center for
Advanced Research in Biotechnology, NIST, Maryland, USA as Guest Researcher.
She joined the staff of the Chemistry Institute in 1986 receiving funds
for her research from CONACyT and DGAPA-UNAM. Ph.D. students and postdoctoral
positions are available in her group.
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RESEARCH
PROJECTS
Our research focuses
on the study of the relationships among protein structure, protein stability
and function. Our specific approach is to use X-ray diffraction, spectroscopic
and calorimetric techniques in biochemical and biological studies of proteins
and some complexes of interest, including protein-protein and protein-carbohydrate
interactions. In the past three years our work has been concentrated in
four distinct areas:
- Contact allergens
from Hevea brasiliensis
- Hydrolytic enzymes
from plants, and marine organisms and enzymes from parasites
- Anti-peptide and
anti-receptor antibodies
- Lectin-carbohydrate
interactions.
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PUBLICACIONES
REPRESENTATIVAS
- Isolation and partial
characterization of giraffine, a lectin from the Mexican endemic alga
Codium giraffa Silva. Alvarez-Hernández S., De-Lara-Isassi G., Arreguín-Espinoza
R., Arreguín B., Hernández-Santoyo A. y Rodríguez-Romero A. Botanica
Marina, 42, 573-580, 1999.
- Crystal structure
of triosephosphate isomerase from Trypanosoma cruzi in hexane. Gao,
Xiu-Gong, Maldonado, E., Pérez-Monfort, R, Garza-Ramos, G., Tuena de
Gómez-Puyou, M., Gómez-Puyou and Rodríguez-Romero A. Proc. Nat. Acad.
Sci. 96, 10062-10067, 1999.
- Stereochemical
metrics of lectin-carbohydrate interactions: comparison with protein-protein
interfaces. E. García-Hernández, R. Zubillaga, A. Rodríguez-Romero y
A. Hernández-Arana. Glycobiology, 10, 975-982, 2000.
- Physicochemical
properties and behavior in solution of three cellulases from Haliotis
fulgens (blue abalone). Hernandez-Santoyo, A., Rojo-Dominguez, A., Garcia-Hernandez,
E., y Rodríguez-Romero, A. Prot. Pept. Letters 7, 389-396, 2000.
- A novel heterodimeric
antimicrobial peptide from the tree-frog Phyllomedusa distincta. Batista,
C.V.F., Scaloni A., Ridgen, D.J., Silva, L.R., Rodriguez-Romero, A.,
Dukor, R., Sebben, A., Talamo, F. and Bloch, C. FEBS Lett. 494, 85-89,
2001.
- Structure and
inactivation of triosephosphate isomerase from Entamoeba histolytica.
Rodriguez-Romero, A., Hernández-Santoyo, A., Del Pozo-Yauner, L., Kornhauser,
A y Fernández-Velasco, A. J. Mol. Biol. 322, 669-675 2002.
- Asclepain, in:
Handbook of Proteolytic Enzymes. A. Rodríguez-Romero and A. Hernández-Arana
Ed. Alan J. Barrett. Academic Press, New York. pg 576-578, 1998. ISBN:
0120793709
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